Blood pressure follows the kidney

Figures & data

Figure 1 The proposed four components of development of hereditary hypertension (A) and how blood pressure regulation could be programmed during perinatal development (B).

Figure 2 Urinary excretions of stable NO metabolites in 4 week-old SHR (open bar) and WKY (horizontal striped bar). #p < 0.001 vs. SHR.

Figure 3 NO yields in kidney (A) and heart (B) determined by electron paramagnetic resonance in SHR (open bars), SHR perinatally supplemented with citrulline (SHRcitr; diagonally striped bars) and WKY (horizontal striped bar).46 ^†p < 0.05, ^‡p < 0.01 and #p < 0.001 vs. SHR.

Figure 4 Systolic blood pressure (A) in control SHR (open circles; n = 24) and SHRcitr (closed circles; n = 16) and WKY (triangles; n = 9).46 WKY was lower than SHR from 8 weeks onwards (p < 0.001). Mean arterial pressure (MAP) at 50 weeks of age (B) in SHR (open bars), SHRcitr (diagonally striped bars) and WKY (striped bars). ^†p < 0.05, #p < 0.001 vs. SHR.

Table 1 Glomerular diameter glomerular density, and kidney weight (mean left and right) of male control and postnatal low-protein (PLP) rats at 12 months of age)

	n	Glomerular diameter (µm)	Glomerular density (n/mm^3)	12 m absolute kidney wt (mg)
Control	12	118 ± 2	53 ± 2	2182 ± 45
PLP	13	109 ± 1#	69 ± 3#	1686 ± 57#

# p < 0.001 vs. control, mean ± SEM.25a

Vaziri ND, Ni Z, Oveisi F. Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 1998; 31:1248 - 1254

 PubMed Web of Science ®Google Scholar

Joles JA, Tarry-Adkins JL, Snoeijs S, van der Giezen DM, Goldschmeding R, Ozanne SE. Reply to: Schreuder. Am J Physiol Regul Integr Comp Physiol 2007; 294:277 - 278

 Web of Science ®Google Scholar