Figures & data
Figure 1 Multi-step bio-response of blood to artificial surfaces.
Figure 2 Complications that occur clinically during ECLS.
Figure 3 Illustration of the surface bound and released factors of the endothelium responsible for its thromboresistivity
Figure 4 Schematic of experimental design used to evaluate the effect of NO-releasing coatings (materials shown beneath the model) on extracorporeal circuits.
Figure 5 SEM pictures of first generation NO-releasing ECC with magnification of the outlined area adjacent. (1a and b) represent the MAHMA/NO doped circuits with and without systemic heparinization, while (2a and b) represent the controls with and without systemic heparinization. Note the dysmorphic platelets seen when systemic heparinization is present and the scarcity of platelet adherence and activation in the presence of an NO-releasing ECC.
Figure 6 Platelet consumption as a function of NO surface flux.
Table 1 NO surface flux as a function of weight percentage of NO donor
Table 2 Hemostatic responses to plastic materials