The peculiar interaction between mammalian prion protein and RNA

Figures & data

Figure 1 Diagram summarizing the findings obtained when rPrP binds either DNA or RNA. While rPrP binds DNA mainly through the C-terminal domain (left), it binds RNA through its N-terminus (right). Small RNAs (SAF93^43–59 and opRNA) bind to PrP but only form small, non-toxic oligomeric species in contrast to N2aRNA binding, which forms large oligomers.