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Shadoo/PrP (Sprn0/0/Prnp0/0) double knockout mice

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Pages 420-424 | Published online: 28 Aug 2012

Figures & data

Figure 1. CNS-expressed prion proteins in mice. PrPC encoded by Prnp and Sho encoded by Sprn are located on different chromosomes. Their adjacent flanking genes (Prnd, Mtg1) are shown and these encode the doppel protein and mitochondrial GTPase 1, respectively. Protein products of Prnp and Sprn are shown but are omitted for Prnd and Mtg1 for the sake of simplicity. Sizes of the transcription units are not to scale and a complex intron/exon structure for Mtg1 has been simplified for the purpose of this figure (slash mark).

Figure 1. CNS-expressed prion proteins in mice. PrPC encoded by Prnp and Sho encoded by Sprn are located on different chromosomes. Their adjacent flanking genes (Prnd, Mtg1) are shown and these encode the doppel protein and mitochondrial GTPase 1, respectively. Protein products of Prnp and Sprn are shown but are omitted for Prnd and Mtg1 for the sake of simplicity. Sizes of the transcription units are not to scale and a complex intron/exon structure for Mtg1 has been simplified for the purpose of this figure (slash mark).