Figures & data
Figure 1. Action of anti-PrP antibody (6D11) on the effects of Aβ oligomers. (A) Object recognition test. two concentrations of 6D11 (0.08 and 0.25 µg) were administered 10 min before the ICV injection of vehicle (VEH) or Aβ oligomers (1µM). The effect of Aβ oligomers was similar in the presence or absence of anti-PrP antibody. (B) Viability of murine hippocampal cell cultures exposed for 48 h to Aβ oligomers (1 µM) with vehicle or 6D11 at 0.25, 0.50 and 2 µg/mL. The presence of PrP antibody did not interfere with the Aβ oligomers toxicity. *p < 0.01 vs respective vehicle (Tukey’s test) for methodological details see Balducci et al.Citation41
