Figures & data
Table 1. Оccurrence of fragmentation-promoting amino acid residues in yeast PrDs
Figure 1. Results of frameshift mutations in polyQ or polyN tracts. (A) frameshift mutations in a polyQ tract encoded by CAA codons result in a tract of polyN. (B) Alignments of portions of the Q/N-rich domains of Cyc8, Pin3 and Rlm1 from various yeast strains. S228, LALV and Y10 denote S228c, LalvinQA23 and Y10 strains of S. cerevisiae. Sequences were taken from the Saccharomyces Genome Database. “˅” depicts the position of deduced frameshift mutations, which convert the sequences of LALV and Y10 proteins into sequences which are nearly identical to the S288 sequence (highlighted in gray).
Figure 2. Alignments of homologs of the yeast prionogenic protein Ure2 and Q/N-rich protein Nab2. Conserved sequences are highlighted in gray. Various types of interspersion of polyQ and polyN indicate that the observed sequences are all descended from a polyQ or polyN tract. Similar divergent interspersion patterns can be observed in PrDs and Q/N-rich domains of many other yeast proteins.
