Implications of prion polymorphisms

Figures & data

Figure 1.Incubation period of Prnp^a and Prnp^b mice infected with scrapie or BSE. (A) Mean incubation period (days) for transmission of spongiform encephalopathy to Prnp^a (open circles) and Prnp^b (open squares) mice from 7 dairy cattle sources, 1 sheep with natural scrapie, 3 cats and 1 sheep, 1 goat and 1 pig that developed clinical disease after experimental infection with BSE (data taken from Bruce et al.¹⁰). (B) Mean incubation period (days) following infection of Prnp^a and Prnp^b mice with 14 scrapie/BSE mouse-adapted strains, 8 isolated from Prnp^a (empty circles) and 6 from Prnp^b (filled squares) mice (data taken from Bruce et al.⁷). (C) Mean incubation period (days) for infection of Prnp^a and Prnp^b mice with 22C, 22A, 79A, and 79V strains (data taken from Bruce et al.⁷). The mean for each set of data are represented by the horizontal line.

Table 1. Incubation periods of first passage prion disease as influenced by mouse Prnp genotype and PrP sequence of mouse-adapted scrapie strain

	PrP^a strain	PrP^b strain
Prnp^a mouse	148–293	214–700
Prnp^b mouse	201–602	115–350

Ranges of first passage incubation periods are given in days for each combination of PrP strain and mouse genotype (data taken from Bruce et al.⁷).

Bruce M, Chree A, McConnell I, Foster J, Pearson G, Fraser H. Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philos Trans R Soc Lond B Biol Sci 1994; 343:405 - 11; http://dx.doi.org/10.1098/rstb.1994.0036; PMID: 7913758

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Prusiner SB. Prion diseases of humans and animals. New York: Ellis Horwood, 1992.

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