Figures & data
Figure 1. SUMO-Interacting Proteins regulate protein activity and stability. A hypothetical transcription factor is SUMOylated, which enhances its transcriptional factor activity or renders it repressive functions (top). SUMO, attached to this transcription factor, could also recruits other proteins such as chromatin remodeling enzymes that may regulate chromatin methylation state (bottom right), or a polySUMO chain can form and this recruits SUMO-Targetd Ub E3 ligases that mediate the turnover of these transcription factors through the 26S proteasome (bottom left).
