Figures & data
Figure 1. FA-like cells with non-functional mitochondria are less sensitive to MMC. (A) Rho-zero cells were prepared by incubating HEK 293 cells with ethidium bromide. (B) Depletion of cells from FANCD2 has been performed by double transfection with FANCD2 siRNA. (C) Cells were incubated for 1 h with 0.5uM MMC (final) or vehicle and MMC sensitivity assay was performed following 24 h post-treatment. (D) Cell sensitivity to MMC is increased for mitochondria-depleted rho-zero HEK293 cells vs. cells with functional mitochondria.
