Figures & data
Figure 1. Left: A control fibroblast from an unaffected individual shows the well-dispersed IF network and the absence of aggregates. Right: A GAN patient fibroblast showing perinuclear vimentin IF aggregation.
Figure 2. Gigaxonin overexpression clears IF in fibroblasts (A) and neurons (B). In neurons this is likely to lead to improvement of axonal transport of organelles such as mitochondria as they are no longer hindered by IF aggregation.
