Figures & data
Figure 1. SETX, SUMO, and the exosome: Working together to fight transcription-related DNA damage. SETX is shown already associated with RNAPII, to resolve any R loops that may form naturally during transcription. Upon transcription and/or replication stress, created for example when RNAPII and DNA polymerase collide, SETX becomes sumoylated. Sumoylated SETX then interacts and/or recruits the exosome through its interaction with Rrp45. SETX resolves the R loop, perhaps inducing RNAPII release from DNA template, while the exosome then degrades the released RNA, to prevent possible reformation of the R loop and/or deleterious effects of the prematurely terminated RNA.
