Figures & data
Figure 1. Regulatory networks involved in translation initiation and points of inhibition. Arrows represent activation, and bars represent inhibition. Small-molecule inhibitors of the signaling nodes are listed below. Abbreviations: 4E-BP, eukaryotic initiation factor 4E–binding protein; AMPK, adenosine monophosphate–activated protein kinase; eEF2, eukaryotic elongation factor 2; eEF2K, eukaryotic elongation factor 2 kinase; eIF2B, eukaryotic initiation factor 2B; eIF4A, eukaryotic initiation factor 4A; eIF4B, eukaryotic initiation factor 4B; eIF4E, eukaryotic initiation factor 4E; eIF4G, eukaryotic initiation factor 4G; GSK3, glycogen synthase kinase 3; Mnk, MAPK-interacting kinase; mTORC1/2, mTOR complex 1/2; RSK 1/2, p90 ribosomal S6 kinase 1/2; PI3K, phosphatidylinositol 3-hydroxy kinase; pdcd4, programmed cell death 4; RTK, receptor tyrosine kinase; S6, ribosomal protein S6; S6K1, S6 kinase 1; TSC1/2, tuberous sclerosis 1/2.
Figure 2. Kaplan-Meier estimates of progression-free survival rates. (A) Using radiographic studies, local investigators assessed the primary end point, progression-free survival. (B) A second assessment was conducted by an independent radiology committee. Reprinted from the New England Journal of Medicine 2012;366:520–9, with permission.
