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Research Articles

Preoperative intranasal dexmedetomidine versus intranasal ketamine for prevention of emergence agitation after sevoflurane in myringotomy patients: A randomized clinical trialFootnote

Page 313 | Received 07 Apr 2017, Accepted 08 Apr 2017, Published online: 17 May 2019

Dear Prof. Raghuraman

I really appreciate your effort and I wish to thank you for your letter in response to my article, entitled: Preoperative intranasal dexmedetomidine versus intranasal ketamine for prevention of emergence agitation after sevoflurane in myringotomy patients: a randomized clinical trial.

1.

Regarding the reference number Citation6 in my article (Chen J, Li W, Hu X, Wang D. Emergence agitation after cataract surgery in children: a comparison of midazolam, propofol and ketamine. Paediatr anaesth. 2010; 20(9): 873–9.) it was wrongly cited, the correct citation is (Abu-Shahwan I, Chowdary K. Ketamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anesthesia. Paediatr Anaesth. 2007; 17(9): 846–50.)

2.

Also, the reference number Citation9 (Khattab AM, El-Seify ZA, Shaaban A, Radojevic D, Jankovic I. Sevoflurane-emergence agitation: effect of supplementary low-dose oral ketamine premedication in preschool children undergoing dental surgery. Eur J Anaesthesiol. 2010; 27(4): 353–8.) was wrongly cited, the correct citation is “Soliman R, Alshehri A. Effect of dexmedetomidine on emergence agitation in children undergoing adenotonsillectomy under sevoflurane anesthesia: A randomized controlled study. Egyptian Journal of Anaesthesia (2015); 31, 283–9.. So, in the discussion, the sentence “Each of ketamineCitation5,6,22 through intravenous route and dexmedetomidineCitation7–9 through the intravenous route were usedmust be corrected to be “Each of ketamineCitation5,6,22 through intravenous route”.

These corrections have been sent to Elsevier Researcher Support team

3.

In the sentence in the discussion section “According to the study of Iirola and his colleaguesCitation23 dexmedetomidine administered intranasally has good bioavailability and its effects were similar to those of intravenous route, was well tolerated, and its maximal effect was after 45–60 min and, (17) myringotomy is a minimally invasive surgery so, pain is excluded as a causative factor for EA” The reference number Citation17 is correctly cited here as although Cimen et al. in their conclusion did not point to the duration of action of intranasally administered dexmedetomidine they found 45 min after drug administration that satisfactory sedation score was found in 100%, satisfactory sedation at parental separation in 74% and the mask acceptance was good or excellent in 80.7% of the intranasal group compared to the buccal group during induction of general anesthesia.

Contribution

Study design and, conduct of the study, data analysis and manuscript preparation.

Publication category

Letter to the editor.

Conflict of interest

None.

Funding source

Self funded.

Notes

Peer review under responsibility of Egyptian Society of Anesthesiologists.

References

  • I.Abu-ShahwanK.ChowdaryKetamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anesthesiaPaediatr Anaesth1792007846850
  • R.SolimanA.AlshehriEffect of dexmedetomidine on emergence agitation in children undergoing adenotonsillectomy under sevoflurane anesthesia: a randomized controlled studyEgypt J Anaesth312015283289
  • Z.S.CimenA.HanciG.U.SivrikayaL.T.KilincM.K.ErolComparison of buccal and nasal dexmedetomidine premedication for pediatric patientsPaediatr Anaesth2322013134138
  • T.IirolaS.ViloT.MannerR.AantaaM.LahtinenM.ScheininBioavailability of dexmedetomidine after intranasal administrationEur J Clin Pharmacol6782011825831