Evaluation of Homonia riparia Lour. for Antiurolithiatic Activity in Albino Rats

Abstract

Ethanol extract of the roots of Homonia riparia was tested for its antiurolithiatic activity against calcium oxalate and magnesium ammonium phosphate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% glycolic acid along with normal feed and magnesium ammonium phosphate stones were induced by implantation of zinc discs in the urinary bladder. The ethanol extract of H. riparia (2 g/kg/day, orally) was found to be effective in reducing deposition of calcium in the kidney of both prophylactic and curative group animals. The extract did not show any significant effect on the activity of the liver enzyme glycolic acid oxidase and on the deposition of oxalate in the kidney. The extract was found to be effective in reducing the formation and also in dissolving the pre-formed magnesium ammonium phosphate type of stones.