Antioxidant Action of an Ethanol Extract of Ptychopetalum olacoides

I.R. Siqueira Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

C.A.S. Cordova Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

T.B. Creczynski-Pasa Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

E. Elisabetsky Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

D.S. Nunes Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

C.A. Netto Departamento de Bioquimica; Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Fisiologia-Biofisica, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil; Departamento de Quimica, Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brazil

Abstract

Alcohol infusions of roots from Ptychopetalum olacoides Bentham (PO; Olacaceae) have been used for treating many diseases in which free radicals are likely to be implicated. Of particular interest are the uses amongst the elderly (to ameliorate cognitive functions), and by patients recovering from pathologies associated with damage to the central nervous system (such as stroke). The aim of this study was to evaluate the antioxidant properties of a PO ethanol extract (POEE) by using various in vitro systems. POEE acted as a scavenger of nitrogen oxides as well as superoxide generated by the xanthine-xanthine oxidase system. The extract also showed a high antioxidant capacity using a luminol chemiluminescence derived from a thermolabile diazocompound. We suggest that the therapeutic effects attributed to P. olacoides could be in part associated to its oxygen free radical scavenging capacity.

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Antioxidant Action of an Ethanol Extract of Ptychopetalum olacoides

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Antioxidant Action of an Ethanol Extract of Ptychopetalum olacoides

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