Abstract
Background. The aim of this study was to determine predictors for loco-regional or distant recurrence of disease in a subgroup of intermediate or high risk stage I and II endometrial cancer. Methods. A retrospective analysis of 295 patients with histopathological stage I and II, intermediate or high risk endometrial cancer is reported. The following factors were studied: stage, grade, age, histologic diagnosis, lymphadenectomy, lymphovascular space invasion, and adjuvant radiotherapy. The Log-Rank test was used for statistical analyses and the Kaplan–Meyer method was used for time-to-event analysis. Multivariate analysis was also performed. Results. Thirty-four (11.5%) patients developed a recurrence; 20 (59%) developed loco-regional recurrence, and 14 (41%) developed distant recurrence. In 20 women (59%), recurrence appeared within 3 years of surgery, and the actuarial survival at 3 years after recurrence was 29%. Multivariate analysis showed that for recurrence, age >60 years was a significant unfavourable prognostic factor (p < 0.05). Conclusions. We found low rates of recurrence in patients with early stage intermediate or high risk endometrial cancer. Only age was identified as an independent significant predictor for recurrence.
| Abbreviations | ||
| ASTEC | = | A study in the treatment of endometrial cancer |
| FIGO | = | International Federation of Gynaecology and Obstetrics |
| LVSI | = | lymphovascular space invasion |
| TAH-BSO | = | total abdominal hysterectomy and bilateral salpingo-oophorecomy |
| PORTEC | = | Post-Operative Radiation Therapy in Endometrial Cancer |
| Abbreviations | ||
| ASTEC | = | A study in the treatment of endometrial cancer |
| FIGO | = | International Federation of Gynaecology and Obstetrics |
| LVSI | = | lymphovascular space invasion |
| TAH-BSO | = | total abdominal hysterectomy and bilateral salpingo-oophorecomy |
| PORTEC | = | Post-Operative Radiation Therapy in Endometrial Cancer |