Growth hormone and cortisol in serum and saliva

Panu J. F. Rantonen Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Ilkka Penttilä Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Jukka H. Meurman Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Kari Savolainen Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Sakari Närvänen Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Tuula Helenius Department of Clinical Chemistry, Kuopio University Hospital, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Surgery, Helsinki University Central Hospital; Children's Hospital, Helsinki University Central Hospital, Medix Clinical Laboratory, Espoo, Finland

Abstract

Salivary diagnosis is a developing area in clinical chemistry and dentistry. Cortisol analyses from saliva have been used in pediatric practice and as doping tests. Growth hormone (hGH), also a stress hormone, has not been analyzed from saliva. We studied the serum and saliva of 51 healthy subjects. The samples were taken at 8:00 in the morning after 12 h fasting. Cortisol concentrations were analyzed using RIA. An immunoradiometric assay was applied for analyzing serum and salivary hGH. The validity of this method developed in our laboratory was found to be good. The results showed correlation of salivary cortisol with that of serum (r = 0.47, P < 0.001). Salivary hGH concentrations were 1000-fold lower than the respective values in serum, but a clear correlation was found between salivary and serum hGH levels (r = 0.59, P < 0.001).

Keywords

Cortisol Diagnosis Growth Hormone Metabolism Saliva Serum

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Growth hormone and cortisol in serum and saliva

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