Abstract
Objective
The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90–95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development of different cancers. Our aim was to investigate the prognostic value of PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs in OOSCC.
Materials and methods
We genotyped 163 OOSCC patients and 146 patients from group of control for PON1 (rs854560 and rs662), TNF-α (rs1800629 and rs361525) and TGF-β (rs1800469) SNPs by real-time polymerase chain reaction (PCR).
Results
TNF-α (rs1800629) GG genotype was significantly more frequent in intraoral lesions and clinical stages III and IV, while the polymorphic AA genotype in lip lesion and clinical stages I and II. Moreover, TGF-β (rs1800469) AG and AA genotypes were significantly more frequent in larger tumours (T3 e T4). TNF-α (rs1800629) AG genotype had poor survival and patients carrying the PON1 (rs662) TT genotype tended to poor survival.
Conclusions
Results suggest that the rs1800629 and rs1800469 could exert influence in the more aggressive behaviour of OOSCC and the genotypes AG of rs1800629, and TT of rs662 could be markers with prognostic value in OOSCC.
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Acknowledgments
This work has in part been presented at the 45th Brazilian Society of Oral Medicine and Oral Pathology (Santos KMS, Santos EM, Santos ITS, et al. Association of PON-1, TNF-α, and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;130(3): e250-e251).
Disclosure statement
The authors declare that they have no conflict of interest.
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