Effect of submicron polyethylene particles on an osseointegrated implant

Mikael Sundfeldt Departments of Biomaterials/Handicap Research, Box 412, SE-405 30 Goteborg, Sweden. E-mail: [email protected], Orthopaedics, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, 3Orthopaedics of Varbergs Hospital, Sweden, 4Joint Replacement Institute of Los Angeles, Orthopaedic Hospital, Los Angeles, CA, USA

Michael Widmark Departments of Biomaterials/Handicap Research, Box 412, SE-405 30 Goteborg, Sweden. E-mail: [email protected], Orthopaedics, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, 3Orthopaedics of Varbergs Hospital, Sweden, 4Joint Replacement Institute of Los Angeles, Orthopaedic Hospital, Los Angeles, CA, USA

Carina B Johansson Departments of Biomaterials/Handicap Research, Box 412, SE-405 30 Goteborg, Sweden. E-mail: [email protected], Orthopaedics, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, 3Orthopaedics of Varbergs Hospital, Sweden, 4Joint Replacement Institute of Los Angeles, Orthopaedic Hospital, Los Angeles, CA, USA

Patricia Campbell Departments of Biomaterials/Handicap Research, Box 412, SE-405 30 Goteborg, Sweden. E-mail: [email protected], Orthopaedics, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, 3Orthopaedics of Varbergs Hospital, Sweden, 4Joint Replacement Institute of Los Angeles, Orthopaedic Hospital, Los Angeles, CA, USA

Lars V Carlsson Departments of Biomaterials/Handicap Research, Box 412, SE-405 30 Goteborg, Sweden. E-mail: [email protected], Orthopaedics, Sahlgrenska University Hospital, Institute for Surgical Sciences, University of Gothenburg, 3Orthopaedics of Varbergs Hospital, Sweden, 4Joint Replacement Institute of Los Angeles, Orthopaedic Hospital, Los Angeles, CA, USA

Abstract

In a rabbit model of a weight bearing, articulating prosthetic joint we repeatedly injected submicron particles of Ultra-High-Molecular-Weight-Polyethylene (UHMWPE) produced in a hip simulator. The contralateral knee with the same prosthesis was injected with carrier (NaCl) without UHMWPE. Histomorphometrical studies on undecalcified cut and ground sections at 26 and 42 weeks involved quantifications of the entire bone to metal contact and the bone area around each implant. We found no statistically significant differences between test and control groups, and the UHMWPE debris did not induce any significant osteolysis, indicating that an osseointegrated implant with a sealed interface may not be affected by UHMWPE debris or progress to aseptic loosening.

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Effect of submicron polyethylene particles on an osseointegrated implant

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