Glycosoaminoglycans in nasal polyps

Abstract

Conclusion The qualitative and quantitative compositions of GAGs were comparable in all the polyps examined.

Objective Glycosoaminoglycans (GAGs) are an integral component of proteoglycans, which are constituents of connective tissue. The qualitative and quantitative compositions of GAGs occurring in proteoglycans determine their biological role. In this work, individual fractions of GAGs occurring in nasal polyps were isolated and estimated.

Material and methods Polyps were obtained over a 2-year period from 31 patients (18 males, 13 females; age range 28–70 years) who underwent polypectomy and evaluated using routine histopathology.

Results The amount of hyaluronic acid in nasal polyps was high, the amounts of dermatane sulphate and chondroitine-6-sulphate were slightly lower and the amounts of chondroitine-4-sulphate, heparin, heparan sulphate and keratan sulphate were the lowest.

• Glycosoaminoglycans
• nasal polyps