Abstract
Objectives: The aim of this study was to investigate the relative frequency of important symptoms of chronic rhinosinusitis with nasal polyps (CRSwNP), the link between CRSwNP and the lower airways and the importance of smoking in CRSwNP.
Method: Three hundred and sixty-eight patients with CRSwNP and 1349 controls were recruited to the study and underwent a structured interview about symptoms from the upper and lower airways, and about smoking habits. Furthermore, all participants were clinically examined using nasal endoscopy.
Results: Due to interactions between the outcome variables, a multiple logistic regression model was fitted to the data. Nasal secretions, nasal blockage and impaired sense of smell were symptoms associated with CRSwNP. Furthermore, male gender, increasing age and asthma were also associated with the disease. Current smoking was less frequent among patients with CRSwNP.
Conclusion: By comparing symptoms and risk factors of patients with CRSwNP with those of a large population-based control group and testing them in a multiple logistic regression model, we have been able to generate data that address key research interests in CRSwNP.
Chinese abstract
目的:本研究的目的是调查具鼻息肉(CRSwNP)的慢性鼻窦炎的重要症状的相对频率、CRSwNP与下呼吸道之间的联系以及吸烟对CRSwNP的重要性。
方法:本研究招收了三百六十八名患有CRSwNP的患者和1349例对照者, 并对他们进行了上呼吸道和下呼吸道症状以及吸烟习惯进行结构性访谈。此外, 所有参与者均接受了鼻内窥镜临床检查。
结果:由于结果变量之间的相互作用, 对数据拟合了多重逻辑斯蒂回归模型。鼻分泌物、鼻塞阻塞和嗅觉受损是与CRSwNP相关的症状。此外, 男性性别、年龄增加和哮喘也与该疾病有关。在CRSwNP患者中较少出现吸烟者。
结论:通过将CRSwNP患者的症状和危险因素与多人群对照组的症状和危险因素进行比较, 并在多元逻辑斯蒂回归模型中进行检测, 得到了CRSwNP的关键研究方向的资料。
Acknowledgements
The authors are grateful to Christel Larson for organizing the meeting with patients and all relatives. We also thank all colleagues around Sweden who examined relatives of our patients, with special thanks to Drs. Dimitrios Michailidis and Annika Brämerson.
Disclosure statement
No conflict of interest exists.