Variation in prognosis of early laryngeal carcinoma after different types of cordectomy with transoral laser microsurgery

Abstract

Background: The lack of standardized treatment is problematic in laser surgery for laryngeal cancer, and may result in an increased recurrence rate. This study analyzed the prognosis of early laryngeal carcinoma after different types of cordectomy with laser surgery.

Methods: A cohort of 818 patients with stage Tis or T1 primary early glottic squamous cell carcinoma treated with CO₂ laser surgery was retrospectively analyzed.

Results: Of the 818 patients, According to the Kaplan–Meier method, the rate of 5-year overall survival was 92.8%, and the rates for 5-year disease-specific survival and 5-year locoregional control were 96.9% and 91.3%, respectively. Among the T1 patients, type II cordectomy with laser surgery had a significant impact on the 5-year locoregional control rate, but no obvious impact on the 5-year overall survival rate.

Conclusions: There must be sufficient depth and extent of excision in T1 patientsand in early carcinoma especially those with possible microinvasive carcinoma

Chinese abstract

背景：喉癌激光手术缺乏标准化治疗, 这是一个问题, 可能会导致复发率增加。本项研究分析了不同类型的激光切除术后早期喉癌的预后。

方法：回顾性分析了818例接受CO2激光手术的Tis或T1期原发性早期声门型鳞癌的患者。

结果：根据Kaplan-Meier方法, 在818例患者中, 5年总生存率为92.8％；5年疾病特定性生存率和5年局部控制率分别为96.9％和91.3％ 。 T1期患者中, II型激光手术切除了对5年局部控制率有显著影响, 对5年总生存率无明显影响。

结论：对于T1期患者和早期癌患者, 特别是可能患微创癌的患者, 必须有足够的切除深度和程度。

Keywords:

• Laryngeal neoplasm
• CO₂ laser
• minimally invasive treatment
• survival analysis

Acknowledgements

The authors wish to thank the numerous individuals who participated in this study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by Hospitals Clinical Medicine Develpoment of Special Funding Support (XMLX201507), National Natural Science Foundation of China [No. 81670946] and Training Programme Foundation for the Outstanding Young Talents of Beijing [2015000021469G227].