309
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Allergy accelerates the disease progression of chronic rhinosinusitis

, , , &
Pages 75-79 | Received 06 Oct 2018, Accepted 18 Nov 2018, Published online: 02 Feb 2019
 

Abstract

Background: The role of allergy in the development of chronic rhinosinusitis (CRS) in East Asians is not clear.

Aims/objectives: The aim was to investigate the impact of allergies in the clinical characteristics of chronic rhinosinusitis.

Material and methods: A total of 138 CRS patients who underwent endoscopic sinus surgery were included. A brief history of rhinosinusitis symptoms, blood eosinophil count, blood-specific allergen tests, computed tomography (CT) scan findings, Lund-Mackay (LM) CT scores, and Sino-Nasal Outcome Test (SNOT-22) Questionnaire scores, and sinoscopy findings at 3 and 6 months postoperatively.

Results: The ImmunoCAP test was positive in 71(51%) patients and negative in 67(49%) patients. The mean age of those who received endoscopic sinus surgery was 7-years younger in the allergic group compared with the non-allergic group (p = .008). The peripheral eosinophil count in the allergic group was higher than that of the non-allergic group (p = .008). The LM scores and SNOT-22 scores were not significantly different between the two groups. The recurrence rate of nasal polyps in the allergic group was higher but without statistical significance.

Conclusions and significance: Allergy may accelerate the disease progression of CRS. The presence of the serum-specific IgE was correlated with peripheral eosinophil percentage, especially in the CRSwNP patients.

Chinese abstract

背景:过敏对于东亚人慢性鼻窦炎(CRS)发病的作用尚不清楚。

目的:研究过敏对慢性鼻窦炎临床特征的影响。

材料与方法:本研究包括138例经鼻内镜鼻窦手术的CRS患者。记录了术后3个月和6个月鼻窦炎症状、血嗜酸性粒细胞计数、血液特异性过敏原测试、计算机断层扫描(CT)结果、Lund Mackay(LM)CT评分和鼻窦-鼻腔结果测试(SNOT-22)问卷评分以及窦境检查结果。

结果:免疫印迹测试阳性71例(51%), 阴性67例(49%)。与非过敏组相比, 过敏组接受鼻内镜手术的患者的平均年龄要年轻7岁(p=.008)。过敏组外周嗜酸细胞计数高于非过敏组(P=.008)。两组间的LM评分和SNOT-22评分没有显著差异。过敏组鼻息肉复发率较高, 但无统计学意义。

结论与意义:过敏可加速CRS的病情进展。血清特定性IgE的存在与外周嗜酸性粒细胞百分比相关, CRSwNP患者尤其如此。

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by the Ministry of Science and Technology [MOST 105-2314-B-002-165].

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 226.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.