Abstract
Primary subglottic carcinoma is rare and surgery is the most common therapeutic strategy for Chinese patients with this disease. To retrospectively evaluate surgically treated primary subglottic carcinoma treated with surgery. Patients with primary subglottic carcinoma who initially underwent surgery from 2005-2010 were grouped by surgical procedures with or without laryngeal function preservation and reviewed. Of 1815 patients with laryngeal cancer, 23 had a subglottic origin. Of these, 21 initially underwent surgery; 12 had ‘early’ (stage I/II) disease, and nine had ‘advanced’ (stage III/IV) disease. The actuarial 5-year OS was 73.9% [95% confidence interval (54.1% ∼ 93.7%)] for patients with squamous cell carcinoma. Among patients with early disease, the 5-year OS and DFS were 80% for partial laryngectomy and 71.4% for total laryngectomy. Patients with advanced disease underwent total laryngectomy, and the 5-year OS and DFS were 62.5%. Satisfactory oncologic outcomes can be achieved with initial surgery. Patients with early disease who underwent partial laryngectomy had a comparable prognosis to those who underwent total laryngectomy; deglutition and speech function were maintained.
Chinese abstract
原发性声门下癌比较罕见。外科手术是我国声门下癌最常见的治疗方法。回顾性评价手术治疗原发性声门下癌的疗效。对2005-2010年初次手术的原发性声门下癌患者按保留或不保留喉部功能的手术方法进行分组并加以回顾。在1815例喉癌患者中, 23例始发于有声门下。其中, 21名患者最初接受了手术;12名患者患有“早期”(I/II期)癌, 9名患者患有“晚期”(III/IV期)癌。鳞状细胞癌患者的实际5年生存率为73.9%【95%置信区间(54.1% -93.7%)】。在早期癌症患者中, 部分喉切除术和全喉切除术的5年OS和DFS分别为80%和71.4%。晚期患者行全喉切除术, 5年OS和DFS为62.5%。初次手术可获得满意的肿瘤学结果。接受部分喉切除术的早期患者与接受全喉切除术的患者预后相当, 并保留了吞咽和语言功能。
Disclosure statement
No potential conflict of interest was reported by the authors.