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Abstract
Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in the Western world in recent years. Human papillomavirus (HPV) infection is established as the main explanation.
Aims/objectives: This study aims to review the most recently published studies on the repartition of HPV-positive OPSCC in Europe.
Method and material: PubMed and Embase were systematically searched for articles addressing the distribution of HPV-positive and HPV-negative cases among OPSCC patients in Europe. Articles published in the period 2014–2018, with a study period including 2013 and the following years were included. The presence of HPV DNA and p16 overexpression, either solely or together, were accepted as indicators of HPV-positivity. Information on the anatomical sublocation of the tumour, definition of HPV-status, HPV type, HPV status, age, sex, TNM-stage, smoking habits and alcohol consumption were extracted.
Results: Seven articles (n = 2075 patients, range: 22–926 patients per study) from seven European countries were included. The repartition of HPV-positivity ranged from 18% to 65%. The lowest occurrence of HPV-positivity was seen in Greece and the Netherlands, and the highest in Sweden and Denmark.
Conclusion/significance: The highest share of HPV-positive patients with up to 65% was found in Nordic countries. The lowest share was found in Central and Southern European countries.
Chinese abstract
背景：近年来, 西方世界口咽鳞状细胞癌（OPSCC）的发病率持续上升。已确定人乳头瘤病毒（HPV）感染是主要原因。
目的：本研究旨在回顾已发表的有关HPV阳性OPSCC在欧洲重新分布的最新研究。
方法和材料：系统搜索了PubMed和Embase, 以查找关于欧洲OPSCC患者中HPV阳性和HPV阴性病例的分布的文章。纳入了2014至2018年期间发表的文章, 未收集2013年之前的数据。单独或一起存在的HPV DNA和p16过表达被认为是HPV阳性的指标。取得有关肿瘤的解剖位置信息、HPV状态的定义、HPV类型、HPV状态、年龄、性别、TNM阶段、吸烟习惯和饮酒的信息。
结果：纳入了来自七个欧洲国家的七篇文章（n = 2075例患者, 范围：每项研究22-926例患者）。 HPV阳性的重新分布范围为18％至65％。 HPV阳性的发生率最低的是希腊和荷兰, 最高的是瑞典和丹麦。
结论/意义：在北欧国家中, HPV阳性患者的比例最高, 高达65％。比例最低的是中欧和南欧国家。
Disclosure statement
The authors report no conflict of interest.