Phonophobia and migraine features in patients with definite meniere’s disease: Pentad or triad/tetrad?

Abstract

Background: Epidemiological studies have shown different association between migraine and Meniere’s disease (MD). Few studies investigated the frequency of phonophobia in MD.

Objectives: This study aimed to determine the frequency of phonophobia and other features of migraine in definite MD.

Material and Methods: Patients with definite MD and a group of healthy (non-MD, non-vertiginous) control subjects participated. Demographic data and other clinical features of the two diseases recorded. Data analyzed in SPSS software version 20, by qi square and independent T test and logistic regression model.

Results: 69 MD patients (average age: 48.87 ± 12.15 years) and 60 control subjects (average age: 47.58 ± 12.05 years) enrolled. The frequency of migraine headache in MD cases was 16% (45% with aura) compared with 5% in control group (three cases; 2 without and 1 with aura) (p < .001). Family history of migraine was the only determinant of the presence of migraine in MD (p = .001, OR = 15.625, 95%CI: 2.94–88.33). The frequency of phonophobia in MD was very high (88.4%: 54.5% in migraine subgroup and 89.6% in non-migraine cases) and without significant relation to existence of migraine, in contrast to photophobia and osmophobia (p = .064).

Conclusions: The frequency of migraine in MD is higher than normal subjects. Phonophobia may be an independent symptom in MD.

Chinese abstract

背景：扁桃体摘除术后延长住院时长至三晚, 以降低扁桃体摘除术后出血所致的死亡率。

目的：评估扁桃体切除术后将住院病人的观察时间从一晚延长到三晚是否有潜在的益处。

研究对象和方法：将1994年至2006年在扁桃体切除术后仅住院一晚的患者（A组）与1570名在2008年至2016年之间术后住三晚的患者（B组）进行比较。比较并发症发生率和住院费用。

结果：已发表的数据显示, A组的6400例患者中有114例（1.78％）发生扁桃体切除术后出血。在该患者组中, 所有出血患者中有75.4％（n¼86）在出院后发生。然而, B组扁桃体切除术后出血发生于70个（4.5％）患者, 其中只有0.38％（n¼6）在术后第二天或第三天发生出血。正如在A组中所观察到的, 大多出血发生在出院后（n¼57； 81.4％）。成本分析显示, 奥地利所有32个ENT部门每年约有600万e的差额。

结论和意义：扁桃体摘除术后将住院时间从一晚延长至三晚并无益处。通过比较表明, 延长住院三晚的费用会大幅增加。

Keywords:

• Meniere’s disease
• migraine
• aura
• phonophobia

Acknowledgment

The authors’ especial thanks to patients and control subjects who participated in this study.

Ethical approval

All the participants had signed written informed consents and all of international/national ethical standards considered in this research.

Disclosure statement

None of the authors had any conflict of interest during this research.

Additional information

Funding

This study was thesis for Medical Doctorate (for T.T Thesis No.1991) funded by Guilan University of Medical Sciences, Deputy of Research and Technology.