ABSTRACT
Background
Patients with locally advanced HPV-positive tonsil cancer would benefit from prophylactic contralateral neck dissection (pCND).
Aims/Objectives
The aim of this study was to analyze rates of contralateral lymph node metastases (LNM) and their prognostic effects on locally advanced HPV-positive tonsillar squamous cell carcinoma.
Materials and methods
Medical records of 54 patients who underwent upfront primary surgery and pCND were retrospectively reviewed.
Results
Six (11.1%) patients had contralateral LNM in 54 locally advanced HPV-positive tonsil cancer. Of these, five patients had contralateral level II LNM and one patient had contralateral level II and III LNM. Contralateral LNM showed significant positive correlations with advanced T stage (p = .017) and the presence of extracapsular spread (p = .007). Contralateral lymph node metastasis had no significant association with five-year disease-specific survival.
Conclusions and significance
This study demonstrated no advantage in performing pCND in early stage HPV-positive tonsil cancer.
Chinese Abstract
背景:局部晚期 HPV 阳性扁桃体癌患者将受益于预防性对侧颈清扫术 (pCND)。
目的:本研究的目的是分析对侧淋巴结转移 (LNM) 的发生率及其对局部晚期 HPV 阳性扁桃体鳞状细胞癌的预后影响。
材料和方法:回顾性审查了接受前期初次手术和 pCND 的 54 名患者的医疗记录。
结果:在 54 例局部晚期 HPV 阳性扁桃体癌中, 6 名(11.1%)患者有对侧 LNM。其中, 5 名患者有对侧 II 级 LNM, 1 名患者有对侧 II 级和 III 级 LNM。对侧 LNM 与晚期 T 期 (p = .017) 和包膜外扩散 (p = .007) 呈显著正相关。对侧淋巴结转移与五年疾病特异性生存率无显著相关性。
结论和意义:本研究表明, 对早期 HPV 阳性扁桃体癌行 pCND 没有优势。
Disclosure statement
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.