Horizontal middle partial laryngectomy with cricothyroidopexy: an effective treatment for stage T1b glottic carcinoma

Abstract

Background

The current treatment options for T1b glottic carcinoma often lead to poor treatment outcomes or voice quality.

Objectives

This study evaluates the therapeutic efficacy of horizontal middle partial laryngectomy with cricothyroidopexy (HMPL-CTP) for stage T1b glottic carcinoma.

Material and Methods

A retrospective analysis was conducted on 73 patients with T1b glottic carcinoma. The patients were categorized into three groups: Group A (n = 22) underwent transoral laser microsurgery (TLMS), Group B (n = 21) received frontolateral vertical partial laryngectomy (FVPL), and Group C (n = 30) underwent HMPL-CTP. The study analyzed the 5-year overall survival rate (OS), recurrence rate, phonatory status, and incidence of laryngeal stenosis.

Results

Voice quality scores varied significantly in the three groups, while the 5-year OS were similar. The local recurrence rate is higher in Group A than in the other two groups. The laryngeal stenosis rate in Group B is higher than in Groups A and C. Adhesions in the anterior commissure were observed in 18 cases in Group A and nine cases in Group C.

Conclusions and Significance

HMPL-CTP demonstrates efficacy as a treatment for stage T1b glottic carcinoma, offering favorable preservation of laryngeal function and minimal complications.

Chinese Abstract

背景: 目前 T1b 声门癌的治疗方案常常导致治疗效果或语音质量不佳。

目的: 本研究评估了用于治疗T1b 期声门癌的水平中段喉切除术伴环甲膜固定术 (HMPL-CTP) 的治疗效果。

材料与方法: 对 73 例 T1b 声门癌患者进行回顾性分析。 患者被分为三组: A 组(n = 22)接受经口激光治疗显微手术 (TLMS), B 组 (n = 21) 接受额外侧垂直向部分喉切除术 (FVPL), 以及C 组(n = 30)接受 HMPL-CTP。 该研究分析了5年总生存率(OS)、复发率、发声状态和喉狭窄的发生率。

结果: 三组的语音质量得分差异显著, 而 5 年 OS 相似。A组的局部复发率高于其他两组。 B组的喉狭窄率高于A组和C组。A组有18例观察到前连合粘连, C组9例。

结论和意义: HMPL-CTP表现出治疗 T1b 期声门癌的功效, 提供良好的喉功能保存和最低的并发症率。

Keywords:

• Laryngeal squamous-cell carcinoma
• partial laryngectomy
• glottis type
• anterior commissure
• recurrence
• laryngeal stenosis

Acknowledgments

N/A

Ethical statement

This study was undertaken with approval from the Ethics Committee of the 900th Hospital of the Joint Logistics Support Force. All the patients signed an informed consent form before their surgery. Consent for participation in this study was waived owing to the retrospective nature of the subsequent analysis.

Authors’ contributions

Shiyan Chen: Investigation; Methodology;

Hongxun Gong: Methodology; Resources; Software;

Ning Huang: Validation; Data curation; Formal analysis;

Fan Yang: Writing - original draft;

Maoxin Wang: Conceptualization, Project administration; Supervision; Writing - review & editing. Funding acquisition.

All of the authors have read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The datasets generated and/or analysed during the current study are available from the corresponding author upon reasonable request.

Additional information

Funding

This work was supported by the Natural Science Foundation of Fujian Province (No.2021J011260).