A 3-hour time interval may not be sufficient for delayed enhancement magnetic resonance imaging with intravenous gadoteridol injection based on 3d-real IR sequence of the inner ear in Meniere’s disease patient

Abstract

Background

Magnetic resonance imaging (MRI) can be applied to visualize endolymphatic hydrops (EH).

Aims/Objectives

To explore whether a 3-h time interval was feasible for clinical practice.

Materials and methods

We prospectively enrolled 15 patients with unilateral Meniere’s disease, each of whom underwent delayed enhancement MRI scan of the inner ear after intravenous gadoteridol injection at a 3-h interval. The ears of these patients were divided into two groups (group A: the affected ears; group B: the unaffected ears). Among the two groups, the signal intensity in perilymphatic area of the basal turn of cochlea, the results of visual evaluations in the vestibule, cochlea and semicircular canal and the detection results of EH were compared.

Results

Regarding the signal intensity, a difference was found between group A and group B (p = .016). Besides, no difference was found between the visual evaluations in the vestibule, cochlea and semicircular canal of the two groups. Regarding the detection results of EH, group A (6 vestibules were undiagnosable; 8 cochleae were undiagnosable); group B (9 vestibules were undiagnosable; 10 cochleae were undiagnosable).

Conclusions and significance

In the clinical application of gadoteridol for the inner ear, 3-h delayed MR imaging may not be sufficient.

Chinese abstract

背景：磁共振成像（MRI）可用于内淋巴积液（EH）的可视化。

目的：探讨 3 小时的时间间隔对于临床实践是否可行。

材料和方法：我们前瞻性地招募了 15 名单侧梅尼埃病患者, 每名患者均间隔3小时静脉注射钆特醇后接受了内耳延迟增强 MRI 扫描。 这些患者的耳朵被分为两组（A组：受影响的耳朵； B 组：未受影响的耳朵）。 两组中, 比较了耳蜗基底转区域外淋巴管信号强度、前庭及耳蜗和半规管的视觉评估结果 以及 EH的检测结果。

结果：关于信号强度, A 组和 B 组之间存在差异 (p=.016)。此外, 两组的前庭、耳蜗和半规管的视觉评估没有发现差异。关于EH检测结果, A组中6个前庭无法确诊, 8个耳蜗无法诊断）； B组中9个前庭无法诊断, 10个耳蜗无法诊断。

结论及意义：钆特醇在内耳临床应用中, 3 小时延迟MR 成像可能还不够。

Keywords:

• Magnetic resonance image
• 3-hour
• gadoteridol
• Meniere’s disease

Authors’ contributions

Wei Chen and Hanyu Xiao designed and conducted research; Yiyin Zhang and Luxi Wang wrote the initial paper; Bingrong Li and Yan Sha revised the paper; Yan Sha had primary responsibility for the final content. All authors read and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by the Shanghai Municipal Science and Technology Commission Biomedicine Division Western Medicine Guidance Project under Grant [19411965700].