Abstract
Data on the increase in pulmonary flow-resistance produced in guinea pigs by exposure to irritants were examined to determine whether animals with higher initial control values showed a degree of response greater than the average. When the data for all irritants was pooled the increase was greater in the animals with high control resistances. When the irritant data was separated as to type (gas, aerosol or gas-plus-aerosol) the difference was not statistically significant for the gas alone but was significant for the other two groups. The differences were most marked when the exposures had been to low concentrations of irritant gas plus inert aerosol and in the ten animals showing the highest initial resistance.
