Abstract
Experiments with high energy neodymium pulsed laser to destroy tumors in mice, rabbits and monkeys, have been conducted at the National Cancer Institute since 1964. These studies indicate that the rapid and precise destruction of localized tumors is possible. When combined with other anticancer modalities a 3 to 4 fold improvement in the cure rate of tumor has occurred. These encouraging results have been overshadowed by secondary effects associated with the laser-tissue interaction. These effects of pressure and varying degrees of cellular damage result in the dissemination of viable tumor into the air and tissue planes resulting in lethal secondary tumor growths. During the course of these studies, protection of laser personnel has been a prime consideration. For the safe operation of equipment, warning beacons, door interlocks, remote operation facilities and special environment conditions are all necessary. Various devices for the containment of the particles in the laser plume have been developed and successfully used.