The Determination of Perphenazine by a New Simple Flow‐Injection Chemiluminescence Method

Abstract

A rapid and simple flow‐injection chemiluminescence (CL) method is described for the determination of perphenazine, which is based on the CL intensity that generated from the redox reaction of Ce (IV)-perphenazine in HNO₃ medium is proportional to the perphenazine concentration without any sensitizers. The proposed method allows the determination range within 1.0×10⁻⁷–7.0 ×10⁻⁵ g mL⁻¹ with a detection limit of 8.0×10⁻⁸ g mL⁻¹, and it has been successfully applied to the determination of the perphenazine in pharmaceutical tablet compared well with the official method.

Keywords:

• Flow injection
• chemiluminescence
• perphenazine
• pharmaceutical tablet

Acknowledgments

We gratefully acknowledge financial support from Xi'an Jiaotong University.