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Analytical Letters Volume 39, 2006 - Issue 15
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Bioanalytical

Quantification of Levosulpiride in Human Plasma by High‐Performance Liquid Chromatography

Tae‐Sung Koo Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, South Korea
,
Mi‐Hwa Kim Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, South Korea
,
Dae‐Duk Kim Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, South Korea
,
Chang‐Koo Shim Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, South Korea
&
Suk‐Jae Chung Ph.D. Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, South KoreaCorrespondence[email protected]
Pages 2809-2822 | Received 23 Mar 2006, Accepted 23 May 2006, Published online: 04 Jan 2007
 
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Abstract

An analytical procedure was developed and validated for the quantification of levosulpiride in human plasma. After subjecting a plasma sample to a two‐step extraction procedure, an aliquot of the aqueous phase was injected onto an high‐performance liquid chromatography system equipped with a fluorescence detector. The detector response was linear for levosulpiride concentrations in the range of 2.5 to 500 ng/ml. The intra‐ and inter‐day precision was below 15.4 and 10.1%, and the accuracy was in a range from 89.7 to 109.4%. The method is applicable for use in the pharmacokinetic characterization of levosulpiride after a 75‐mg oral dose in humans.

This study was supported by the Korea Health Industry Development Institute (KHIDI).

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