Voltammetric Determination of Rosiglitazone in Pharmaceutical Preparations and Human Plasma

Abstract

The voltammetric behavior of rosiglitazone was studied using direct current (DC_t), differential pulse (DPP), and alternating current (AC_t) polarography. The drug manifests cathodic waves over a pH range of 2–11.2. In Britton‐Robinson buffer (BRb; pH 4), the diffusion current–concentration relationship was found to be rectilinear over a range of 4–24 µg · mL⁻¹ and 0.1–16 µg · mL⁻¹ using DC_t and DPP modes, respectively, with minimum limits of detection (LOD) of 0.15 µg · mL⁻¹ and 0.07 µg · mL⁻¹ using the DC_t and DDP modes, respectively. The diffusion‐current constant (I _d) was 6.63±0.03 (n=5). The proposed method was successfully applied to the determination of the studied compound both in pure form and in formulations. The mean percentage recoveries in tablets were 100.09±1.18 and 100.85±0.88 (n=5) using DC_t and DPP modes, respectively. Furthermore, the proposed method, adopting the DPP mode, was applied to the determination of rosiglitazone in spiked human plasma and the obtained mean percentage recoveries were 99.14±3.29 (n=4).

Keywords:

• Rosiglitazone
• polarography
• dosage forms
• spiked human plasma