Abstract
A single-sweep voltammetric method was proposed for the determination of tamoxifen. The proposed method took advantage of both the accumulation of carbon paste electrode toward tamoxifen and the rapidity of single-sweep voltammetry. In HAc-NaAc (pH 4.1) buffer/methanol (85:15 v/v) mixed solution, an irreversible oxidation peak of tamoxifen was observed at 1.1 V (versus SCE). The second-order derivative peak current of tamoxifen and its concentration plots were rectilinear over the range of 7.0 × 10−10 ∼ 3.0 × 10−8 mol · l−1 with a detection limit of 1.0 × 10−10 mol · l−1 without any preconcentration. The proposed method was evaluated by analyzing tamoxifen citrate tablets, which was characterized by rapidity and higher sensitivity.
Thanks for the financial support of the National Natural Science Foundation of R. P. China (Grant No. 20475043). Thanks to Kunshan Sanyou Pharmaceutical Co. Ltd., China, for supplying tamoxifen standard.