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MOLECULAR IMPRINTED POLYMERS

Preparation and Application of a Novel Silica-Supported Organic-Inorganic Hybrid Molecular Imprinting Polymer

, , , &
Pages 1811-1817 | Received 18 Mar 2008, Accepted 03 Apr 2008, Published online: 16 Jun 2010
 

Abstract

A novel estazolam-imprinted silica sorbent was prepared by the surface imprinting technique using 3-aminopropyltriethoxysilane (APTEOS) and phenyltrimethoxysilane (PTMOS) as functional monomers. The functional monomers are expected to form hydrogen bonds and π-π interactions with estazolam. The imprinted silica sorbent was characterized by Fourier transform infrared spectroscopy (FT-IR), element analysis, and scanning electron micrograph (SEM). Compared to C18 solid phase extraction (SPE) and liquid-liquid extraction, molecular imprinting polymer (MIP) SPE was the most feasible method to extract estazolam from human plasma, and the recovery of estazolam was up to 98.7±1.2%.

The Program Foundation of Science of Guangdong Province (No.2005B30101016) and The Natural Science Foundation of Guangdong Province (No.31503) is gratefully acknowledged.

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