A Selective Solid-Phase Extraction and Preconcentration Method with Using Molecularly Imprinted Polymer for Piroxicam in Pharmaceutical Sample

Abstract

A powerful sample cleanup procedure using molecularly imprinted polymer as a solid phase extraction material for the preconcentration of piroxicam in pharmaceutical samples has been developed. The optimized conditions for the preparation of molecularly imprinted polymer as a selective sorbent for the preconcentration of this drug were also studied. It is very important to note that a preconcentration factor of 1000 and retention capacity of 30.0 mg/g can be achieved. Recoveries up to 95% were accomplished for the analyte of interest from a pharmaceutical piroxicam capsule sample. All of these experiments were also performed with nonimprinted polymer.

Keywords:

• Molecularly imprinted polymer
• piroxicam
• preconcentration
• solid-phase extraction

We wish to express our gratitude to the research Affairs Division and Research Council and Center of Excellency in Sensor of Isfahan University of Technology (IUT) for financial support of this work.