Rapid Determination of Pentazocine in Human Plasma and Urine by a Potentiometric Method

Abstract

A fast potentiometric determination method has been reported for pentazocine in human plasma without complicated pretreatments using a coated-wire potentiometric selective electrode. The sensing membrane was made by incorporating of ion-association complexes of pentazocine cation and sodium tetraphenyl borate (NaTPB) in a polyvinyl chloride. The sensor exhibited fast, stable, and linear Nernstian response over the range of 5 × 10⁻⁵ to 0.1 mol L⁻¹ pentazocine with a slope of 57.8 mV per decade and with detection limit of 3.2 × 10⁻⁵ mol L⁻¹. The proposed sensor has been used for determination of pentazocine in human plasma and urine.

Keywords:

• Coated wire
• pentazocine
• pharmaceutical samples
• plasma
• potentiometry
• urine

Acknowledgments

The authors express their appreciation to the Isfahan University of Technology Research Councils and Center of Excellence in Sensors for financial support of this work.

Notes

*Dibutyl phthalate (DBP); Dioctyl phthalate (DOP); 2-Nitrophenyloctylether (NPOE); Dioctylsebacate (DOS).

^a Shows the standard deviation for three-replicate analysis.