Enantioanalysis of Butaclamol Using Enantioselective Potentiometric Electrodes

Abstract

Three enantioselective, potentiometric electrodes were proposed for the enantioanalysis of butaclamol. The electrodes were based on immobilization of maltodextrins (MDs) of different dextrose equivalences [4.0–7.0, I; 13–17, II; 16.5–19.5, III] into carbon paste. The electrodes based on MD I and II were used for the enantioanalysis of S-butaclamol within linear concentration ranges of 10⁻¹⁰ to 10⁻⁷ and 10⁻¹⁰ to 10⁻⁸, respectively, with slopes of 51.20 and 57.59 mV/decade of concentration; whereas the electrode based on MD III was used for the enantioanalysis of R-butaclamol within a linear concentration range between 10⁻¹⁰ and 10⁻⁷ with a slope of 58.50 mV/decade of concentration. Recoveries greater than 90% were recorded for the enantioanalysis of butaclamol in synthetic and urine samples.

Keywords:

• Butaclamol
• enantioanalysis
• enantioselective
• maltodextrin
• potentiometric electrode

Acknowledgments

The authors dedicate this article to the memory of Professor George G. Guilbault.

Notes

Note. All measurements were made at room temperature, and all values are the average of 10 determinations.

Note. All measurements were made at room temperature, and all values are the average of 10 determinations.

Note. All measurements were made at room temperature, and all values are the average of 10 determinations.

Note. All measurements were made at room temperature, and all values are the average of 10 determinations.