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Abstract
The preparation of a methacrylate polymer molecularly imprinted (MIP) with paracetamol (APAP) was performed. After extraction of the APAP template molecule, the MIPs were incorporated into a graphite–polyurethane (GPU) matrix, and the resulting composites were used to prepare modified electrodes intended to be used in APAP determination. The best results were found using a 2.5% MIP in the GPU electrode and a 500-µm MIP particle size. This electrode was used in the determination of APAP in pharmaceutical formulations, reaching a 6.7 × 10−8 mol L−1 limit of detection. The 2.5% MIP-GPU-modified electrode showed better sensitivity than the nonimprinted methacrylate GPU-modified electrodes. Interference of phenacetin in the APAP response decreased remarkably when the proposed electrode was used.
The authors are indebted to the Brazilian agency FAPESP for P. C.'s postdoctoral fellowship (06/06133-9) and financial support (08/03537-7). We also appreciate the valuable help with EIS and for-point-contact measurements performed by Fernando C. Moraes (DQ-UFSCar) and William F. Alves (EMBRAPA-São Carlos), respectively.
Notes
a Resistance of solution.
b Resistance of electron transfer.
c Electron-transfer rate constant.
d Unmodified.
a Result ± standard deviation (n = 2).
b Two determinations.
Notes. E1: DPV vs. HPLC (DPV – HPLC/HPLC) × 100%. E2: DPV vs. labeled (DPV – labeled/labeled) × 100%.