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Analytical Letters Volume 43, 2010 - Issue 5
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CHROMATOGRAPHY

Simplex-Stochastic Resonance Algorithm Applied to Detection of Weak Chromatographic Peaks

Liyan Yu Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, China
,
Wei Zhang Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, China
,
Bingren Xiang Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, ChinaCorrespondence[email protected]
,
Shaofei Xie Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, China
,
Haishan Deng Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, China
&
Rongmei Sun Center for Instrumental Analysis, China Pharmaceutical University, Key Laboratory of Drug Quality Control and Pharmacovigilance under the Ministry of Education, Nanjing, China
Pages 851-857 | Received 17 Apr 2009, Accepted 06 Aug 2009, Published online: 24 Feb 2010
 
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Abstract

The simplex-stochastic resonance algorithm (SSRA) was applied to amplification and detection of the weak High Performance Liquid Chromatography (HPLC) chromatographic signals of coumatetralyl in plasma. In this algorithm, modified simplex algorithm was embedded to greatly enhance the signal-to-noise ratio of chromatographic signals. The application of SSRA to detect HPLC/UV weak signals of coumatetralyl showed an excellent quantitative relationship between different concentrations and responses. The assay was linear over the concentration range of 3–100 ng/mL, r = 0.9997, and RSD < 10%. The good linearity and precision demonstrated that it is an effective algorithm for detecting weak chromatographic peaks.

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