Polar-Embedded and Polar-Endcapped Stationary Phases for LC

Abstract

Polar-embedded and polar-endcapped phases have become widespread over the past decade. When compared to classical alkylsilicas, they offer an alternative selectivity profile, increased stability in highly aqueous mobile phases, and improved peak shape for basic analytes. This mini-review summarizes current knowledge and applications of these phases, including the recent development of a series of N-methylamide embedded phases, prepared using supercritical carbon dioxide.

Keywords:

• Liquid chromatography
• Polar-embedded
• Polar-endcapped
• Stationary phase

This article was submitted as part of a Special Memorial Issue honoring Prof. George G. Guilbault.