Simultaneous Determination of Dopamine and Uric Acid by Electrocatalytic Oxidation on a Carbon Paste Electrode Using Pyrogallol Red as a Mediator

Abstract

A sensitive and selective electrochemical method for the simultaneous determination of dopamine (DA) and uric acid (UA) was developed using a pyrogallol red modified carbon paste electrode. Under the optimized conditions, the peak current was linearly dependent on 1.0–700.0 μmol L⁻¹ DA and 50.0–1000.0 μmol L⁻¹ UA. The detection limits for DA and UA were 0.78 μmol L⁻¹ and 35 μmol L⁻¹, respectively. Finally, this method was also examined for the determination of DA and uric acid in real samples such as drugs and urine.

Keywords:

• Carbon paste electrode
• Dopamine and uric acid
• Electrocatalytic
• Pyrogallol red

The authors wish to thank the Isfahan University of Technology (IUT) Research Council and Center of Excellence in Sensor (IUT) for support of this work.

Notes

*LOD: Limit of detection