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Analytical Letters Volume 44, 2011 - Issue 4
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BIOANALYTICAL

In Vitro Electrochemical Study on Combined Cytotoxicity of 5-Fluorouracil and Three Types of Nanoparticles Against MG-63 Cells

Xiangfu Jiang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. China; College of Life Science, Tarim University, Alar, China
,
Liang Tan Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. ChinaCorrespondence[email protected]
,
Baoling Zhang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. China
,
Yaping Zhou Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. China
,
Shouzhuo Yao Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. China
&
Qingji Xie Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, P.R. ChinaCorrespondence[email protected]
Pages 698-708 | Received 23 Sep 2009, Accepted 02 Dec 2009, Published online: 16 Mar 2011
 
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Abstract

The individual and combined cytotoxicity of 5-fluorouracil and the three nanoparticles, silica, selenium, and gold nanoparticles against human osteosarcoma MG-63 cells were investigated by using cyclic voltammetry and microscopic observation, respectively. It is found that both the drug and the nanoparticles were able to inhibit cell proliferation in a dose-dependent way and the inhibition efficiency of Au NPs was most prominent. The combination of 5-FU with high-concentration SiO2 NPs and Se NPs presented a simple-addition and synergistic effect, respectively. The present work may be conducive for the exploration of the applications of nanoparticles in biomedicine and cancer treatment.

Acknowledgments

This work was supported by the National Science Foundation of China (20905025, 90713018, 20975037, and 20705008), the State Special Scientific Project on Water Treatment (2009ZX07212-001-06), the Scientific Research Fund of Hunan Provincial Education Department (09B062), and the Doctor Startup Fund of Hunan Normal University (090607).

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