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Original Articles

Electrochemical Oxidation of Derivatives of Dibenzodiazepin. Dibenzothiazepin and Dibenzoxazepin

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Pages 1217-1234 | Received 18 Apr 1979, Accepted 19 May 1979, Published online: 05 Dec 2006
 

Abstract

Clozapin exhibits two anodic waves at ≥ 1 M H2SO4, but at lower acidities only the first two-electron wave remains. Cyclic voltammetry shows an ECE mechanism. Reversibility decreases at ≥ 10−4 M concentrations, due to formation of an adsorptiob film. In nonaqueous solvents two irreversible one-electron waves appear. Clothiapin and loxapin are more difficultly oxidized and can be measured in the presence of clozapin.

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