Flow Injection and Related Techniques in Blood Studies for Clinical Screening and Analysis: A Review

Abstract

Blood studies for clinical screening/analysis are geared toward point of care testing. Flow based techniques have expanded their applications with unique approaches that may be adaptable for use as alternative disease screening/diagnosis. Many newly developed systems for solution based chemical analysis can be easily adapted for use with plasma and serum. However, cell and intracellular analyses are different. Blood cell analyses require a particular way of sample introduction and detection. This review emphasizes the applications of flow based techniques, especially those that were coupled with FI/SI, in clinical studies through analysis of red blood cells and their intracellular substances.

Keywords:

• Blood studies
• Flow injection
• Intracellular substances
• Microfluidics
• Red blood cell
• Review
• Sequential injection

Acknowledgments

This paper was submitted as part of a Special Issue on Flow Injection Analysis.

The authors thank the Thailand Research Fund (TRF), the Commission on Higher Education, and the Center for Innovation in Chemistry (PERCH-CIC) for support.