Pharmacokinetic Parameters of Statin Drugs Characterized by Reversed Phase High-Performance Liquid Chromatography

Abstract

The aim of this study was to evaluate the usefulness of reversed-phase high performance liquid chromatography in building models that would allow prediction of ADME (absorption, distribution, metabolism, and elimination) parameters of statin drugs in humans. The retention time of each drug was measured using C-18 and C-8 columns with an eluent acetonitrile-water. Furthermore, chromatographic data were compared with physicochemical properties and ADME data calculated by use of 17 different software programs. According to obtained results the calculated values correlate fairly well with chromatographic data which confirm the utility of liquid chromatographic technique for determination of pharmacokinetic parameters.

Keywords:

• ADME
• in silico approach
• Lipophilicity
• RP-HPLC

Acknowledgments

This work was supported through a grant (Investigation of new methods in analysis of drugs and bioactive substances, no. 006-0061117-1240) from the Ministry of Science, Education and Sports of the Republic of Croatia.

Notes

*Correlation coefficients above 0.900 are highlighted.