Chip-On-Valve Concept: An Integrated Platform for Multisyringe Flow Injection Analysis: Application to Nitrite and Nitrate Determination in Seawater

Abstract

A state-of-the-art flow lab-on-a-valve technique is reported incorporating integration of flow devices such as reaction and mixing serpentine coils and confluences into a monolith flow circuit mounted directly on an eight-port selection valve. The potential of the flow circuit manifold or chip-on-valve in combination with multisyringe flow injection analysis is demonstrated by the application to the successful determination of nitrite and nitrate in seawater. Characteristics and further potential of chip-on-valve are discussed. Due to preparation and fabrication by use of computer aided design, this chip design shows great potential for the automation of sophisticated flow networks in compact and robust flow circuits.

Keywords:

• Chip-on-valve
• Microconduit chip
• Multisyringe flow injection analysis
• Nitrate
• Nitrite
• Seawater

Acknowledgments

B. Horstkotte was funded by a JAE Postdoctoral fellowship from CSIC. The work was supported by the Spanish Ministry of Science and Innovation, project CTQ2010-15541, and by the Government of the Balearic Islands, project 43/2011.

Notes

R1: 17% Phosphoric Acid; R2: 50 g/L Sulfanilinic acid pH12; R3: 10 g/L Naphthylenediamine dihydrochloride.

*Mean of 4 repetitions.