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BIOANALYTICAL

Disposable Stochastic Sensors for the Simultaneous Assay of Acetylcholine and Dopamine in Whole Blood Samples

, &
Pages 1927-1934 | Received 28 Sep 2017, Accepted 17 Oct 2017, Published online: 28 Mar 2018
 

ABSTRACT

Acetylcholine and dopamine are neurotransmitters important for aging and brain pathology. Their assay in whole blood is essential for fast and early detection of neurodegenerative disorders. Therefore, polymeric textile covered with a thin layer of Ag was used to provide stochastic sensors modified with maltodextrins presenting different dextrose equivalence: Maltodextrin I (dextrose equivalence 13.0–17.0), and Maltodextrin II (dextrose equivalence 16.5–19.5). These stochastic sensors were used reliable for both qualitative and quantitative analysis of acetylcholine and dopamine in whole blood samples. Their sensitivity and selectivity were high, and they were reliable for the assay of dopamine and acetylcholine in whole blood samples, with recoveries higher than 98.00%, and relative standard deviations (%) values lower than 1.00%.

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