Ultrasonic-Assisted Extraction of Chlorogenic Acid from Capillary Artemisia with Natural Deep Eutectic Solvent-Functionalized Cellulose

Abstract

Ultrasonic-assisted extraction methods have been applied in many fields in recent decades. In this study, chlorogenic acid was isolated from capillary artemisia ultrasonically using the designed poly (natural deep eutectic solvents-ethylene glycol dimethacrylate) cellulose. The actual quantity of chlorogenic acid extracted was 62.83 mg g⁻¹dry powder using the following optimal conditions: raw material to liquid ratio of 1:40 g mL⁻¹, extraction temperature of 80 °C, ultrasonic power of 160 W, and extraction time of 40 min. The limit of detection for chlorogenic acid in capillary artemisia was 0.14 µg mL⁻¹, and the intraday and interday precision values as the relative standard deviation (n = 6) after spiking with 5, 100, and 500 µg mL⁻¹ were both less than 4.21%. This paper reports an effective method that provides facile operation, is low cost, and has excellent selectivity for chlorogenic acid in capillary artemisia.

Keywords:

• Capillary artemisia
• cellulose
• chlorogenic acid
• HPLC
• natural deep eutectic solvents
• ultrasonic-assisted extraction technique

Disclosure statement

The authors declare that they have no financial and personal relationships with other people or organizations that can inappropriately influence the work, and there is no professional or other personal interest of any nature or kind in the manuscript entitled “Ultrasonic-assisted extraction of chlorogenic acid from capillary artemisia with natural deep eutectic solvent-functionalized cellulose”.

Ethical statement

This article does not contain any studies with human participants or animals.

Additional information

Funding

This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT: Ministry of Science and ICT) [grant number NRF-2019R1A2C1010032].